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. 2021 Jul 12;12:4251. doi: 10.1038/s41467-021-24524-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A The percentage of subjects (n = 7) who, by caregiver report, experienced irritability at baseline compared to the last available follow-up timepoint (Month 24 for Subjects 1–3, Month 18 for Subjects 4 and 5, and Month 6 for Subjects 6 and 7). B The number of hours or irritability per day recorded in caregiver diaries increased slightly immediately after surgery, and then improved on average (mean ± SE). C Prevalence and severity of insomnia before and after gene delivery by caregiver report. D The mean number of hours (±SE) of night-time sleep recorded in caregiver diaries improved slightly across subjects after gene delivery. For Subject 2 (blue triangles), the improvement was dramatic. E–G Prevalence and severity of other non-motor symptoms before and after gene delivery by caregiver report (see details in A, above). Major (black): frequent and/or severe, with significant impact on comfort or function; Minor (gray): infrequent and/or mild. Source data are provided as a Source Data file.