Figure 1.

Accumulation of germline and recurrent somatic variants in DDR and non-DDR interactors in the NetDDR network. Percentages of protein-coding genes with variant annotations in COSMIC and ClinVar are shown in panels (a,b), respectively. Patterns of recurrent somatic (≥ 2 samples) and germline variants in the highly mutated DDR genes are illustrated in panels (c,d), respectively. An additional analysis of the variant distributions, normalized by protein length, is shown in Supplementary Fig. S6.