Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jul 12;11:14268. doi: 10.1038/s41598-021-93715-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Co-localization of germline and somatic variants in ATM, BRCA1, BRCA2 and MUTYH. Panel (a): Histograms and density distributions for different types of variants in ATM. The histograms in the left-hand column show the counts of each variant type in bins of 75 residues along the sequence. They show: germline variants identified in different cohorts of mCRPC collected from the literature (PubMed), germline variants from TCGA, germline variants from ClinVar, and somatic variants from COSMIC. Where more than one type of variant is plotted the widths of the bars in each bin are reduced accordingly. To the right of each histogram are the equivalent density distributions, as computed by smoothing the histogram bars. A small version of the Pfam domain layout is also shown beneath the histograms and density distributions. Panels (b–d) show the data for BRCA1, BRCA2, and MUTYH, respectively.