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. 2021 Jul 12;11:390. doi: 10.1038/s41398-021-01517-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — C57BL/6 mice received a single IV injection of recombinant HMGB1 protein (rHMGB1, 32.5 μg) or vehicle and mRNA was assessed in the midbrain 3 H later. PPM transcriptome genes (A) Gzma, (B) C3, (C) Cd72, (D) Il2rg, (E) Cd69, and (F) Cxcl10 mRNA levels were measured in the midbrain. Male C57BL/6 mice received a single IP injection of LPS or saline and neuroinflammation was assessed 3 H or 7 days later and PPM gene expression levels were compared: (G) Gzma, (H) C3, (I) Cd72, (J) Il2rg, (K) Cd69, and (L) Cxcl10 mRNA levels were measured in the isolated microglia. mRNA levels were analyzed by qRT-PCR and normalized to Gapdh using the 2-ΔΔCT method. Data are reported as the mean ± SEM. *p < 0.05 and **p < 0.01 when compared to control (n = 4–6).