Table 1.

MDSC genes differentially expressed between FEC + oHSV-1 and oHSV-1 treatments.

Gene	O vs. S	F + O vs. O	Function
S100A9	2730.36	−9.79	Associated with MDSC-mediated resistance to chemotherapy67,68
			Implicated in MDSC-driven metastasis69
			Associated with MDSC activation and suppressive function70
CXCL3	411.80	−5.87	MDSC activation and recruitment71,72
CXCR2	345.58	−6.20	Phenotypic marker of MDSCs73
			Myeloid cell differentiation and migration in the tumor microenvironment72,74
			MDSC recruitment75
CSF3	282.48	−9.38	Gene encoding G-CSF, critical to the accumulation of MDSCs69
S100A8	242.56	−6.44	Implicated in MDSC-driven metastasis69
CXCL2	233.83	−5.11	MDSC proliferation and chemotaxis67,72
			MDSC activation and recruitment72
CXCL1	120.11	−7.78	MDSC activation and recruitment72
TREM1	45.37	−3.01	MDSC marker76
NOS2	44.63	−4.06	MDSC-driven metastasis and T-cell suppression69
ARG2	41.34	−3.11	Associated with MDSC-mediated suppression70
LY6G	16.52	−7.04	Phenotypic marker of MDSCs72,73
			MDSC-driven metastasis69
SLPI	10.04	−1.96	MDSC differentiation77,78
FPR2	9.38	−2.00	Receptor for SAA3, a well-known inflammatory factor that connects MDSCs with cancer progression79
IL1R1	5.43	−4.11	MDSC-driven metastasis80
ADAM19	5.34	−3.47	STAT pathway differentiation of MDSCs81
SERPIND1	4.41	−4.23	MDSC proliferation and migration82
ITGB2	3.73	−1.98	MDSC effector function83
LY6C1	3.05	−4.17	Phenotypic marker of MDSCs67,72,73,84
PEAR1	2.76	−3.47	MDSC differentiation85
FYN	2.02	−1.71	Differentiates MDSCs from DCs86
CD38	1.94	−1.39	Phenotypic marker of MDSCs73
SOCS1	1.65	−1.25	MDSC induction87
ATRAID	1.22	−1.21	MDSC differentiation73,88,89