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. 2021 Jul 12;10(7):48. doi: 10.1038/s41389-021-00339-6

Fig. 4. Pharmacological inhibition of DOT1L leads to the alteration of multiple genes that affect the growth of ovarian cancer cells.

Fig. 4

A Schematics of the RNA sequencing analysis performed with IGROV-1 and SK-OV-3 cells. B Heatmaps show the overall alterations of gene expression in IGROV-1 and SK-OV-3 cells treated with 10 μM EPZ-5676 for 48 h in comparison with control cells. C Venn diagrams show the genes that were significantly upregulated (n = 97) or downregulated (n = 68) in both cell lines (IGROV-1 and SK-OV-3) after treatment with 10 μM EPZ-5676 for 48 h. D A bar diagram shows the pathways that were downregulated in both ovarian cancer cell lines after treatment with 10 μM EPZ-5676 for 48 h. E A bar diagram shows the pathways that were upregulated in both ovarian cancer cell lines after treatment with 10 μM EPZ-5676 for 48 h.