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. 2021 Jul 12;10(7):48. doi: 10.1038/s41389-021-00339-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A Heatmaps show the overall metabolite alterations in IGROV-1 cells treated with 10 μM EPZ-5676 for 48 h in comparison with control cells. B Expression level of metabolite that were significantly altered in IGROV-1 cells treated with 10 μM EPZ-5676 for 48 h relative to that in control cells. C Diagram showing the metabolic pathways that were measured in global large-scale metabolomics analysis along with the significantly altered metabolites, which are indicated with a pink star. D Metabolic pathways that were associated with significantly altered metabolites in IGROV-1 cells treated with 10 μM EPZ-5676 for 48 h. E ULBP1 mRNA and protein expression in IGROV-1 cells treated with 10 μM EPZ-5676 for 48 h compared with that in control cells. F Schematics of NK cell-mediated cytotoxic assay. G Bar diagram showing the percentage of NK cell cytotoxicity in IGROV-1 cells treated with 10 μM EPZ-5676 for 48 h compared with the cytotoxicity in control treated cells. Data were shown as the mean ± SEM, *p < 0.05, **p < 0.01, ***p < 0.001, ns not significant, calculated using the Student’s t-test.