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. 2021 Jun 29;15:691988. doi: 10.3389/fnins.2021.691988

FIGURE 2.

FIGURE 2

Effect of biofeedback on functional connectivity of the prefrontal cortex. (A) Positive interaction contrast time × group revealing higher increases of functional connectivity of the VMPFC from T1 to T2 in the biofeedback group compared to the control group (voxel-level: p < 0.005 uncorr., cluster-level: p < 0.05 FDR-corrected). (B) Change of connectivity from T1 to T2 in the middle cingulate cortex. (C) Change of VMPFC-connectivity from T1 to T2 in the right amygdala. (D) Change of VMPFC-connectivity from T1 to T2 in the left anterior insula was correlated to the increase of HRV (Pearson r = 0.61, p < 0.05). SMA, supplementary motor area; MCC, middle cingulate cortex; aIns, anterior insula.