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. 2021 Jul 12;11:14324. doi: 10.1038/s41598-021-93498-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Discovery phase results. (A) Volcano plot of the discovery study. The y-axis represents − log10 p-value, and the x-axis represents the log2 fold change. Values greater or less than 0 indicate upregulated and downregulated genes, respectively. Color and opacity indicate whether features had a significant nominal p-value (red and opaque) or not significant (grey and transparent). Labeled features are those with a nominal p-value < 0.05 and |logFC|> 0.5 or p-value < 0.01. (B) Boxplots of RFU levels of the three selected protein candidates replicated from the discovery study (n = 24). The y-axis represents log(RFU) and the x-axis represents the group (controls, grey; cases, orange). *: P-value < 0.01. ASAH2, neutral ceramidase; MET, hepatocyte growth factor receptor; MMP9, matrix metalloproteinase-9; RFU, relative fluorescence units.