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. 2021 Jul 12;11:14324. doi: 10.1038/s41598-021-93498-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Enriched Reactome and Gene Ontologies (biological processes and molecular functions) pathways in the proteomic data. 5 Reactome pathways, 21 GO molecular functions, and 2 GO biological processes were significantly enriched (q-value < 0.25). Red circles: upregulated processes in patients with progression of WMH; blue circles: downregulated processes. 5 pathways were significantly enriched (at q-value < 0.25) regarding the Reactome, 21 considering GO molecular function and 2 considering GO biological processes. This figure was constructed with Cytoscape software (version 3.8.2, 2001–2018 Cytoscape Consortium, https://cytoscape.org/). Annotations correspond to the most frequent words in each cluster.