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. 2021 Jul 12;11:14319. doi: 10.1038/s41598-021-93590-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of the activation of the pathways in the brain and the spinal cord at different stages of the disease. Heatmap of the Z-scores of the canonical pathways in the brain and the spinal cord at the pre-onset and the symptomatic stage of the disease. It is sorted in ascending order of the Z-score for pre-onset brain and spinal cord. p53 pathway has been added to the pre-onset data to highlight the absence of these pathways until symptomatic disease.