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. 2021 Jul 12;12:4245. doi: 10.1038/s41467-021-24499-6

Fig. 4. Tfeb downregulation decreases proliferation of Tsc-deficient cells.

Fig. 4

a Confirmation of shRNA knockdown of TFEB in Tsc2+/+ and Tsc2−/− MEFs (n = 3 biological replicates per condition). b Proliferation of Tsc2+/+ and Tsc2−/− MEFs with Ctrl or Tfeb shRNA assessed by crystal violet staining (n = 12 biological replicates per condition). c Tumor volume of Tsc2−/− MEFs with Ctrl or Tfeb shRNA#2 subcutaneously injected into immunodeficient mice (n = 10 each group). Graphs are presented as mean ± SD. Statistical analyses were performed using two-tailed Students t-test, **p < 0.01, ****p < 0.0001. Source data are provided as a Source data file.