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Effect of GSK2193874 against NMDA-induced seizures and death in rats
| Tonic-clonic seizures | Latency for seizure onset (s) |
Mortality | |
|---|---|---|---|
| NMDA | 95% (19/20) | 363.5 ± 173.8 | 45% (9/20) |
| Memantine + NMDA | 90% (18/20) | 627.4 ± 224.1 * | 0% (0/20) *** |
| GSK2193874 + NMDA | 65% (13/20) *# | 1096.9 ± 558.9 *# | 10% (2/20) *** |
Data are shown as the mean ± SD, *P < 0.05, ***P <0.001 vs NMDA group; #P <0.05 vs Memantine + NMDA group.
