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. 2021 Jul 12;11:14269. doi: 10.1038/s41598-021-93774-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Scatter diagrams between age and mean QTcI values of all ECG measurements in all study time-points (top panel), standard deviation of QTcI values of all ECG measurements in all study time-points (middle panel), and subject-specific log-linear QT/RR slope (bottom panel). In each panel, the red circles and blue squares correspond to female and male subjects, respectively. The solid red and solid blue lines show the linear regressions between the age and the measured QT characteristics in females and males, respectively. The red shaded and blue shaded areas are the 95% confidence intervals of the regression lines; the violet areas are the overlaps between the confidence intervals of the sex-specific regressions. ms milliseconds.