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. 2021 Apr 29;37(7):1039–1050. doi: 10.1007/s12264-021-00693-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Synaptic and non-synaptic neuron-OPC communication. A Schematic of neuron-OPC communication in the brain, including direct soma-soma (A1) and synaptic contact (A2). B–D OPC somata (PDGFRα⁺, red) are in close contact with neuronal somata (NeuN⁺, green) (arrows) in cortex (ctx, B and C) and hippocampus (hc, D). Micrographs in B and C are from the cortex of NG2-CreER^T2 × Rosa26-CAG-lsl-tdTomato mice [6, 133]. Images were acquired by confocal laser-scanning (LSM710, B and C) or automated epifluorescence microscopy (AxioScan.Z1) (D) with appropriate filters and objectives. Scale bars, 20 μm for B and 50 µm for D.