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. 2021 Jun 29;12:627533. doi: 10.3389/fphar.2021.627533

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Copyright © 2021 Seiwerth, Milavic, Vukojevic, Gojkovic, Krezic, Vuletic, Pavlov, Petrovic, Sikiric, Vranes, Prtoric, Zizek, Durasin, Dobric, Staresinic, Strbe, Knezevic, Sola, Kokot, Sever, Lovric, Skrtic, Blagaic and Sikiric.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(Left, control), (right, BPC 157). Fibrosis and BPC 157 therapy. Summarized gross evidence. Presentation of the bile duct ligation rats (“yellow rats”) following 4 months of occlusion (as a model of the wound-healing response to chronic liver injury), gross rat presentation (C1), and after sacrifice, yellow ears (C2), and liver presentation (C3) (Sever et al., 2019). Possible analogy goes with the dermal, muscle (proximal and distal stump of quadriceps muscle poorly connected at day 72 after transection (c)), tendon (gap after tendon detached from calcaneus (C)) and ligament fibrosis and scar formation, and failed function (Mikus et al., 2001; Krivic et al., 2006; Staresinic et al., 2006; Cerovecki et al., 2010). In rats with bile duct ligation, BPC 157 counteracts cirrhosis and portal hypertension (gross rat presentation (B1), and after sacrifice, normal ears (B2), and liver presentation (B3)) much like it attenuates dermal, muscle (well-formed quadriceps muscle at day 72 after transection (b), tendon (tendon reattached to the calcaneous after detachement (B)), and ligament fibrosis and scar formation, and regained function (Mikus et al., 2001; Krivic et al., 2006; Staresinic et al., 2006; Cerovecki et al., 2010).