FIGURE 13.

Healing of the segmental osteoperiosteal bone defect (0.8 cm, in the middle of the left radius) in rabbits (Sebecic et al., 1999). Incompletely healed defect in all controls (assessed during 6 weeks, in 2-weeks intervals (c1 (week 2), c2 (week 4), and c3 (week 6)). Pentadecapeptide BPC 157 beneficial effect was consistently obtained (either percutaneously given locally (10 μg/kg) into the bone defect, or applied intramuscularly (intermittently, at postoperative days 7, 9, 14, and 16 at 10 μg/kg) or continuously (once per day, postoperative days 7–21 at 10 microg or 10 ng/kg)) (b1 (week 2), b2 (week 4), and b3 (week 6)). Comparative regimens included percutaneous administration of autologous bone marrow locally (2 ml, postoperative day 7) as well as an autologous cortical graft inserted in the bone defect immediately after its formation. Saline-treated (2 ml intramuscularly (i.m.) and 2 ml locally into the bone defect), injured animals were used as controls (Sebecic et al., 1999).