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. 2021 Jun 29;12:627533. doi: 10.3389/fphar.2021.627533

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Copyright © 2021 Seiwerth, Milavic, Vukojevic, Gojkovic, Krezic, Vuletic, Pavlov, Petrovic, Sikiric, Vranes, Prtoric, Zizek, Durasin, Dobric, Staresinic, Strbe, Knezevic, Sola, Kokot, Sever, Lovric, Skrtic, Blagaic and Sikiric.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Tracheocutaneous fistulas and BPC 157 therapy. After injury induction, BPC 157 dissolved in saline (10 μg, 10 ng/kg body weight) given per-orally in drinking water till the sacrifice (0.16 μg/ml, 0.16 ng/ml, and 12 ml/day/rat). At postsurgery day 7, fistula closure, closed tracheal defect, and closed skin defect (B, b) (arrow) were observed in BPC 157 rats. Contrarily, in controls, fistula remained open, fistulous channel was formed in the skin, and open tracheal defects were observed (C, c) (arrow) (HE, x4).