FIGURE 6.

Perforated cecum defect and BPC 157 therapy effect. i. Presentation of the perforated cecum defect (o-immediately after perforation, before therapy) as an illustration of the rapid healing effect immediately after wounding, with vessels “running” toward the defect augmented by BPC 157 bath application (10 μg/kg) (USB microcamera). b—vessels recruitment presentation immediately under the immersion of the BPC 157 bath, which had been applied at the cecum, and presentation immediately thereafter →b) with corresponding controls (saline bath 1 ml/rat) presentation c, →c). ii. Resultant bleeding from the perforated defect (C (controls), decreased in BPC 157 rats (B). iii. Final failure of the perforated defect healing in controls (C) (postinjury day 7) and completely healed defect in BPC 157 rats (B). This beneficial effect goes along with counteraction of the worsening effect of both NOS-blocker L-NAME (5 mg/kg), or NOS substrate L-arginine (100 mg/kg) (directly applied to the perforated cecum, alone or combined, and spread through the abdominal cavity), and normalization of the increased MDA- and NO-values in the cecum (Drmic et al., 2018).