Table 1.
Background characteristics of study population according to development of posthepatectomy liver failure
| Overall (n = 67) |
Grade B or C PHLF |
P † | ||
|---|---|---|---|---|
| Yes (n = 8) | No (n = 59) | |||
| Background data | ||||
| Age (years)* | 71 (42–88) | 72 (59–81) | 71 (42–88) | 0·641‡ |
| Sex ratio (M : F) | 40 : 27 | 7 : 1 | 33 : 26 | 0·087 |
| BMI (kg/m2)* | 21·9 (15·0–30·7) | 19·5 (16·7–24·2) | 22·2 (15·0–30.7) | 0·012‡ |
| Child–Pugh grade | 0·119 | |||
| A | 66 (99) | 7 (88) | 59 (100) | |
| B | 1 (1) | 1 (12) | 0 (0) | |
| C | 0 (0) | 0 (0) | 0 (0) | |
| Preoperative management | ||||
| Portal vein embolization | 0·035 | |||
| Yes | 19 (28) | 5 (63) | 14 (24) | |
| No | 48 (72) | 3 (37) | 45 (76) | |
| Biliary drainage | 0·093 | |||
| Yes | 48 (72) | 8 (100) | 40 (68) | |
| No | 19 (28) | 0 (0) | 19 (32) | |
| Preoperative blood tests * | ||||
| Total bilirubin (mg/dl) | 0·70 (0·21–2·15) | 0·91 (0·70–2·15) | 0·66 (0·21–1·92) | 0·003‡ |
| AST (units/l) | 33 (9–99) | 29 (16–57) | 33 (9–99) | 0·529‡ |
| ALT (units/l) | 45 (7–227) | 40 (17–227) | 45 (7–206) | 0·504‡ |
| Albumin (g/dl) | 3·6 (2.8–4·6) | 3·4 (2·8–4·1) | 3·7 (2·8–4·6) | 0·089‡ |
| Prothrombin time (%) | 90·2 (71·1–130·0) | 79·9 (75·6–92·2) | 90·6 (71·1–130·0) | 0·018‡ |
| Platelet count (×104/μl) | 22·9 (8·4–48·6) | 26·7 (13·6–45·3) | 22·7 (8·4–48·6) | 0·219‡ |
| ICGK* | 0·18 (0·10–0·28) | 0·15 (0·10–0·22) | 0·18 (0·12–0·28) | 0.020‡ |
| ICGK-F* | 0·09 (0·04–0·16) | 0·06 (0·04–0·08) | 0·09 (0·06–0·16) | < 0·001‡ |
| CT volumetry-related parameters | ||||
| FLRV (ml)* | 514 (336–1208) | 379 (336–510) | 536 (353–1208) | < 0·001‡ |
| FLR proportion (%)* | 35 (40–87) | 38 (37–50) | 52 (35–87) | 0·004‡ |
Values in parentheses are percentages unless indicated otherwise;
*
values are median (range). AST, aspartate aminotransferase; ALT, alanine aminotransferase; ICGK, plasma clearance rate of indocyanine green (ICG); ICGK-F, future liver remnant (FLR) plasma clearance rate of ICG; FLRV, FLR volume.
†
Continuous variables were compared using the Wilcoxon rank sum test, while categorical variables were compared using the χ2 test or Fisher’s exact test as appropriate.
‡
Wilcoxon rank sum test.