Table 4. Summary of the Articles Included in the Review .

AMI: Acute myocardial infarction; B.P.: Blood pressure; CHD: Chronic heart disease; CVD: Cardiovascular diseases; D.M.: Diabetes Mellitus; ESRD: End-stage renal disease; F: Female; FMD: Flow-mediated Dilation; HTN: Hypertension; LDL: Low-density lipoprotein; M: Male; RCT: Randomized Control Trial; TRF: Tocotrienol rich fraction; U.K.: United Kingdom; U.S.: United States

Author	Year	Location	Study type	Population	Results/Conclusion
Prentice et al. [15]	2019	U.S.	Cohort	3780 all female (F)	No significant association of vitamin E in decreasing CVD risk.
Huang et al. [16]	2019	Finland	Cohort	29133 all male (M)	Men with higher vitamin E status had significantly lower overall mortality and cause-specific mortality due to CVD found during 30 years of follow up independent of several other mortality risk factors.
Lee et al. [17]	2018	China	Cohort	875 (M=456, F=419)	Increased dietary intake of vitamin E was significantly associated with decreased risk of long term cardiovascular outcome during 22 years of follow up in people with  age 44.7+/-11.5 years
Eshak et al. [18]	2017	Japan	Cohort	58696 (M=23099, F=35597)	Higher intake of vitamin E or vitamin D, vitamin K was associated with lower cardiovascular mortality risk in women but not in men during the median follow up  of 19.3 years.
Alshiek et al. [34]	2017	Israel	RCT	20 (M=9, F=11)	Significant improvement of vascular function following eight weeks of treatment with vitamin E in type 2 D.M. patients with hp2-2 gene who were of age >55 years.
Minotti et al. [12]	2017	Italy	Cross-sectional	615 all M	Vitamin E to the total intake of calories was inversely associated with impaired flow-mediated dilation (FMD) of the brachial artery. The impaired FMD is a marker of early arterial vascular dysfunction, which is an important feature of atherosclerosis.
Zhao et al. [19]	2017	China	Cohort	134358 (M=59739)	Total carotene and vitamin C level was inversely associated with CVD mortality and all-cause mortality; however, vitamin E was not associated with either of them during a long follow-up period (8.2 years for male, 14.2 years for female).
Godala et al. [27]	2017	Poland	Case-control	191 (M=101 F=90)	Serum vitamin E level together with vitamin A, C, and D was significantly low in people aged 30 to 65 with metabolic syndrome.
Stepaniak et al. [20]	2016	Russia, Poland, Czech	Cohort	26993 (M=12642 F=14351)	No clear association between vitamin E intake and CVD/mortality. No significant protective effect of vitamin E or vitamin C, beta carotene against CVD.
Stone house et al. [35]	2016	South Australia	RCT	87 (M=54, F=33)	Eight weeks supplementation of palm tocotrienol TRF-80 (420 mg/day tocopherol+132 mg/day tocotrienol) significantly increased the level of serum vitamin E; however, it did not significantly affect vascular endothelial function and other markers of CVD.
Llopis- González et al. [26]	2015	Spain	Case-control	1514 (M=752, F=762)	No significant association of hypertension with the intake of vitamin E in people of age >40 years
Kuwabara et al. [13]	2014	Japan	Cross-sectional	3507 (M=1405, F=2102)	Higher vitamin E intake was associated with a low prevalence of HTN significantly  in people of age >40 years
Hodgson et al. [36]	2014	Australia	RCT	55 (M=41, F=14)	Vitamin E was not associated significantly with day time or night time B.P. variation in Type2 D.M. patients of mean age 61.3 years
Xu et al. [28]	2014	China	Case-control	60 (M=26, F=34)	An acute increase in blood sugar can damage the vascular endothelial function, especially in hypertensive patients. This effect was reversed significantly by a high  dose of vitamin E and/or vitamin C.
Cangemi et al. [21]	2013	Italy	Cohort	1012 (M=55%, F=45%)	Low serum vitamin E was associated with an increased number of cardiovascular events such as myocardial infarction, ischemic stroke, and cardiovascular death in a  patient with non-valvular atrial fibrillation.
Wannamethe et al. [22]	2013	U.K.	Cohort	3919 All M	Serum vitamin C but not vitamin E was found to be significantly associated with the reduced risk of heart failure in men with or without preexisting MI.
Otero-Losada et al. [37]	2013	Argentina	RCT	112 (M=51, F=61)	Serum alpha-tocopherol level was increased only in people with pretreatment alpha-tocopherol less than that of recommended serum level otherwise, there was  no effect of supplementation of 400mg alpha-tocopherol daily for two months. No association between atherosclerotic cardiovascular disease and supplementation of vitamin E was found.
Espe et al. [23]	2013	Germany	Cohort	1046 (M=565, F=481)	Serum alpha-tocopherol level was not significantly associated with cardiovascular outcome and all-cause mortality in diabetic hemodialysis patients.
Goyal et al. [24]	2013	U.S.	Cohort	16008 (M=7510 F=8498)	Lower or higher serum level of vitamin E was significantly associated with increased risk of all-cause mortality. However, it was not associated with cardiovascular  disease/mortality.
Baldi et al. [38]	2012	Austria	RCT	37	Vitamin E supplementation increased the resistance of LDL to oxidation after hemodialysis in 18 patients on chronic hemodialysis due to ESRD despite the fact that each dialysis session acutely increases LDL oxidizability.
Naidoo et al. [29]	2012	Singapore	Case-control	699 (M=456, F=243)	Alpha and gamma-tocopherol were not associated with an increased or decreased risk of acute myocardial infarction (AMI). However, delta-tocopherol was significantly associated with an increased risk of AMI.
Chae et al. [33]	2012	U.S.	RCT	39815 all F	Vitamin E was not associated with the overall risk of heart failure in females aged >45 years, who were healthy at baseline, on 10.2 years of median follow-up time.
Nagao et al. [30]	2012	Japan	Case-control	38158 (M=13382 F=24776)	No significant association was found between alpha or gamma-tocopherol and coronary heart disease. Serum alpha-tocopherol was associated with decreased total and hemorrhagic stroke mortality in females, while gamma-tocopherol was associated with increased hemorrhagic stroke mortality in females but lower ischemic stroke mortality  in men.
Ferro et al. [25]	2012	Italy	Cohort	144 (M=83, F=61)	Low serum vitamin E level was associated with increased risk of atrial fibrillation recurrence in patients who underwent  cardioversion.
Yildiran et al. [14]	2011	Turkey	Cross-sectional	66 all M	Vitamin E intake in 35 men with CHD was lower than in 31 men without CHD (p<0.05) aged between 40-65 years.