Table 1.
Human autophagy gene and diabetes associations
| Nearby/mapped gene identified* | Disease association | Autophagy association | SNPs | Study accession no. |
|---|---|---|---|---|
| CDKN1B | T2D | Macroautophagy | rs2066827 | GCST009379 |
| BCL2 | Τ2D | Macroautophagy | rs12454712 | GCST004894, GCST009379, GCST010118, GCST007847 |
| CAMKK2 | T2D | Macroautophagy | rs3794205 | GCST005414 |
| MAP2K7 | T2D | Macroautophagy | rs4804833 | GCST009379 |
| CALCOCO2 | T2D | Selective autophagy (xenophagy) | rs10278 | GCST007517 |
| VEGFA | T2D | Macroautophagy | rs11967262 | GCST009379 |
| PTEN | T2D | Macroautophagy | rs1236816 | GCST010118 |
| CLN3 | T1D | Macroautophagy | rs151234 | GCST009875 |
| CLEC16A | T1D | Macroautophagy, selective autophagy (mitophagy) | rs741172 | GCST009875 |
| CTSH | T1D | Macroautophagy | rs34593439 | GCST009875 |
*
This table was generated by cross-referencing mapped/nearby genes from published T1D and T2D GWAS polymorphisms with the human autophagy database. This table reflects the identified gene, the autophagy pathway associated with that gene, and the nearby SNP used to identify the gene.