Table 1.

Plausible positive effects of statins in COVID-19 patient

Antiviral	Antireplicative viral activity Inhibition of entry virus into host cells
Anti-inflammatory	Increasing the expression of ACE-2 Inhibiting Toll-like receptor (TLR)–MYD88–NF-кB Reduction of C-reactive protein (CRP)
Anti-thrombotic	Decreased tissue factor expression Decreased platelet aggregation Increased thrombomodulin expression on endothelial cells
Anti-fibrosis	Inhibition of ROCK activity Reduction of TGFβ1 and PDGFβ
Reduction of vascular endothelial dysfunction	Increasing endothelial NO synthase (eNOS)