Comparison 3. Group 3: NSAIDS (ibuprofen 1200 mg,arthrotec, rofecoxib 25 mg, naproxen) vs Acetaminophen.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Rest pain	4	594	Std. Mean Difference (IV, Fixed, 95% CI)	‐0.19 [‐0.35, ‐0.03]
2 HAQ Pain	2	341	Std. Mean Difference (IV, Random, 95% CI)	‐0.22 [‐0.77, 0.33]
3 Pain on motion (walking)	2	271	Std. Mean Difference (IV, Fixed, 95% CI)	‐0.03 [‐0.27, 0.21]
4 50 Foot Walk Time	3	571	Std. Mean Difference (IV, Fixed, 95% CI)	0.03 [‐0.14, 0.19]
5 HAQ disability index	2	341	Std. Mean Difference (IV, Fixed, 95% CI)	‐0.14 [‐0.36, 0.07]
6 Physician Global (Dichotomous)	1	123	Risk Ratio (M‐H, Random, 95% CI)	1.15 [0.75, 1.77]
7 Patient Global (Dichotomous)	3	1190	Risk Ratio (M‐H, Random, 95% CI)	1.50 [1.27, 1.76]
8 Toxicity 1 (Total number of Patients with any AE)	6	2039	Risk Ratio (M‐H, Fixed, 95% CI)	1.02 [0.92, 1.14]
9 Toxicity 2 (Withdrawals due to toxicity)	6	1908	Risk Ratio (M‐H, Fixed, 95% CI)	0.94 [0.68, 1.30]
10 WOMAC Pain	2	1000	Std. Mean Difference (IV, Fixed, 95% CI)	‐0.37 [‐0.50, ‐0.24]
11 WOMAC Stiffness	2	998	Std. Mean Difference (IV, Fixed, 95% CI)	‐0.38 [‐0.51, ‐0.25]
12 WOMAC Function	2	1000	Std. Mean Difference (IV, Fixed, 95% CI)	‐0.40 [‐0.53, ‐0.27]
13 WOMAC Total	1	217	Std. Mean Difference (IV, Fixed, 95% CI)	‐0.46 [‐0.73, ‐0.19]
14 Overall Pain (multiple methods)	7	1812	Std. Mean Difference (IV, Fixed, 95% CI)	‐0.31 [‐0.40, ‐0.21]