Table 2.
Relative expression of superoxide dismutase isoforms (Cu/Zn Sod, Mn Sod, and EC Sod), glutathione peroxidase 1 and 4 (Gpx1, Gpx4), and catalase (Cat) genes in female aortas. Data are presented as arithmetic mean ± SD (two-way ANOVA)
Female aortas | Cu/Zn Sod* | MnSod† | EC-Sod‡ | Gpx1§ | Gpx4‖‖ | Cat⁋ |
---|---|---|---|---|---|---|
Control |
0.99 ± 0.63 (N = 4) |
0.09 ± 0.36 (N = 5) |
0.23 ± 0.25 (N = 5) |
0.09 ± 0.05 (N = 5) |
0.19 ± 0.20 (N = 5) |
1.01 ± 0.79†† (N = 5) |
Carbohydrate- and fat-rich diet (HSHFD) |
0.61 ± 0.33 (N = 6) |
0.09 ± 0.08 (N = 7) |
0.15 ± 0.08 (N = 6) |
0.08 ± 0.04 (N = 7) |
0.19 ± 0.11 (N = 7) |
0.84 ± 0.50†† (N = 5) |
HSHFD+metformin |
0.55 ± 0.64**(N = 6) |
0.07 ± 0.06 (N = 5) |
0.15 ± 0.23 (N = 6) |
0.08 ± 0.07 (N = 6) |
0.04 ± 0.02 (N = 6) |
1.12 ± 0.90†† (N = 7) |
HSHFD+liraglutide | 1.48 ± 0.33** (N = 4) | 0.30 ± 0.20 (N = 4) | 0.70 ± 0.55 (N = 4) | 0.24 ± 0.18 (N = 4) | 0.14 ± 0.10 (N = 5) | 13.99 ± 2.92 (N = 4) |
*Cu/Zn Sod (P = 0.1026, F = 2.22).
†MnSod (P = 0.7179, F = 0.4513).
‡EC-Sod (P = 0.2289, F = 1.512).
§Gpx1 (P = 0.2512, F = 1.426).
‖‖Gpx4 (P = 0.5166, F = 0.7716).
¶Cat (P < 0.0001, F = 78.42).
**HSHFD+liraglutide vs HSHFD; HSHFD+metformin (Cu/Zn Sod P < 0.05), Bonferroni post hoc test, P < 0.05.
††HSHFD+liraglutide vs HSHFD; HSHFD+metformin; control (Cat P < 0.05), Bonferroni post hoc test, P < 0.05.