Logistic regression models for 28 d mortality by D-dimer category. Model 1 is unadjusted. Model 2 is adjusted for age, sex, race, body mass index, diabetes mellitus, hypertension, coronary artery disease, chronic obstructive pulmonary disease, current smoking status, and active malignancy. Model 3 is further adjusted for receipt of invasive mechanical ventilation, shock, and the renal, coagulation, and liver components of the Sequential Organ Failure Assessment score, each assessed within the first 2 d following ICU admission. Model 4 is further adjusted for home anticoagulation as well as receipt of therapeutic anticoagulation, aspirin, and steroids in the first 2 d following ICU admission. Covariates are further defined in the Supplemental Methods (Supplemental Digital Content 1, http://links.lww.com/CCM/G206). ULN = upper limit of normal.