TABLE 1.

Main substrates and dephosphorylating sites of TCPTP.

Substrates	Dephosphorylating sites	Related signaling	References
JAK1	Y1022 and Y1023	IFN-γ, IL-2 signaling	Simoncic et al., 2002
JAK3	Not reported	IL-2 signaling	Simoncic et al., 2002
STAT1	Y701	IL-6, IL-7, IFN-γ signaling	ten Hoeve et al., 2002
STAT3	Y705	IL-6, IFN-γ, leptin signaling	Yamamoto et al., 2002; Zhang Y. et al., 2018
STAT5	Y694 and Y699	IL-2, GH, leptin signaling	Yu et al., 2000
STAT6	Not reported	IL-4 signaling	Lu et al., 2007; Lu et al., 2005
IR	Y1162 and Y1163	Insulin signaling	Galic et al., 2003
EGFR	Y992 and Y1068	EGF/EGFR/PI3K signaling	Scharl et al., 2010b
VEGFR	Y1054/1059,Y1214 and Y996	VEGF/VEGFR signaling	Mattila et al., 2008
PDGFR	Y1021 and Y751	PDGF/PDGFR signaling	Kramer et al., 2020
CSF-1R	Y807	CSF-1/CSF-1R signaling	Zhang et al., 2019