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. 2021 Jun 29;12:653521. doi: 10.3389/fphar.2021.653521

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Copyright © 2021 Qi, Zhang, Wang, Kong, Zhai, Fang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Global response rate for patients of CR (A), PR (B), ORR (C), DCR (D), 1-year OS rate (E), and 6-months PFS rate (F). The global response rate consists of CR, PR, ORR, and DCR. The global CR was 1.26% (95% CI, 0.35–2.54; I², 19.10), PR was 7.65% (95% CI, 3.32–13.37; I², 76.40), ORR was 9.85% (95% CI, 4.40–16.95; I², 81.60), and DCR was 18.33% (95% CI, 12.1827.59; I², 79.20) (A–D). 1-year overall survival rate and 6-months progression-free survival rate were 43.34% (95% CI, 35.70–51.15; I², 68.70), and 17.24% (95% CI, 10.70–23.78; I², 67.80) (EF).