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. 2021 Jun 29;12:653521. doi: 10.3389/fphar.2021.653521

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Copyright © 2021 Qi, Zhang, Wang, Kong, Zhai, Fang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Global response rate and risk estimate between PD-1+ and PD-L1− for patients of ORR (A) and DCR (B). The ORR was 10.62% (95% CI, 4.67–16.56; I², 78.80) vs. 3.07% (95% CI, 0.00–6.43; I², 0.00) [RR, 2.935 (1.189, 7.244)]; the DCR was 17.95% (95% CI, 12.61–25.55; I², 51.30) vs. 4.71% (95% CI, 1.81–12.25; I², 00.00) [RR, 3.584 (1.337, 9.608)].