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. 2021 Jun 29;12:653521. doi: 10.3389/fphar.2021.653521

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Copyright © 2021 Qi, Zhang, Wang, Kong, Zhai, Fang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Global incidence of AEs in any grade (A), in severe grade (B), irAEs (C), discontinue (D), and death (E). The overall incidence of AEs was 64.18% (95% CI, 60.43–68.17; I², 0.00) in any grade and 12.94% (95% CI, 10.36–15.76; I², 00.00) in severe grade. The incidence of irAEs was 14.75% (95% CI, 11.72–18.06; I², 47.0). Besides, the incidence of discontinue and death due to treatment-related AEs was about 3.06% (95% CI, 1.68–4.44; I², 45.50) and 0.31% (95% CI, 0.000.92; I², 0.00), respectively.