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. 2021 Jun 29;12:653521. doi: 10.3389/fphar.2021.653521

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Copyright © 2021 Qi, Zhang, Wang, Kong, Zhai, Fang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Detailed incidence of treatment-related AEs in any grade (A) and in severe grade (B). When the specific AEs reported in at least two studies were analyzed, treatment-related AEs of any grade that occurred in at least 5% of patients were fatigue (18%), nausea (12%), diarrhea (9%), hypothyroidism (8%), arthralgia (7%), asthenia (7%), decreased appetite (7%), pruritus (7%), and rash (6%) (A); treatment-related AEs of severe grade that occurred in at least 1% of patients were anemia (2%), autoimmune hepatitis (2%), diarrhea (2%), fatigue (1%), GGT increased (2%), nausea (1%), and pneumonitis (1%) (B).