FIGURE 8.

Schematic figure related to global response rate and survival rate (A), schematic figure related to PD-L1 expression-associated response rate (B), and schematic figure concerning adverse events and related discontinue or death events (C). More than 17% patients could survive 6 months without disease progression, and over 43% patients could survive 1 year or more (A); when compared PD-L1+ with PD-L1− patients, the CR was 2.52 vs 0.00%, the PR was 9.93 vs. 2.69%. Additionally, PD-L1+ patients even have approximately 3 times ORR and 3.6 times DCR of PDL1− patients (B); nearly 65% patients treated with anti–PD-1/PD-L1 agents experienced at least one adverse event, and 13% patients suffered from at least one grade 3 or higher adverse event. As for irAEs, nearly 15% patients experienced one irAEs (C).