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. 2021 Jun 29;12:653521. doi: 10.3389/fphar.2021.653521

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Copyright © 2021 Qi, Zhang, Wang, Kong, Zhai, Fang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Treatment-related AEs of any grade that occurred in at least 5% of patients (A), treatment-related AEs of severe grade that occurred in at least 1% of patients (B), and chematic figure concerning primary immune-related AEs (C). Treatment-related AEs of any grade that occurred in at least 5% of patients were fatigue (18%), nausea (12%), diarrhea (9%), hypothyroidism (8%), arthralgia (7%), asthenia (7%), decreased appetite (7%), pruritus (7%), and rash (6%) (A); treatment-related AEs of severe grade that occurred in at least 1% of patients were anemia (2%), autoimmune hepatitis (2%), diarrhea (2%), fatigue (1%), GGT increased (2%), nausea (1%), and pneumonitis (1%) (B); as for irAEs, manifesting as hypothyroidism (7%) was most common, and hyperthyroidism (3%), pneumonitis (3%), and infusion-related reaction (2%) were relatively less common (C).