FIGURE 3.

Serum concentrations of the eight best-performing and common proteins in predicting pulmonary arterial hypertension (PAH) in the DETECT Discovery Cohort and the Sheffield Confirmatory Cohort: a) collagen IV, b) endostatin, c) insulin-like growth factor binding protein (IGFBP)-2, d) IGFBP-7, e) matrix metallopeptidase (MMP)-2, f) neuropilin-1, g) N-terminal pro-brain natriuretic peptide (NT-proBNP) and h) RAGE (receptor for advanced glycation end products). PH: pulmonary hypertension. Boxes indicate median and interquartile range; whiskers indicate the full range of the data. Individual patient samples are represented by dots. p-values from the Wilcoxon rank-sum test between the two patient groups.