Figure 4.

High 12-chemokine scores correlated with higher densities of tumor infiltrating immune cells. Immunohistochemistry was performed using antibodies to CD4, CD8, CD20, and LAMP3 to mark CD4+ T cells, CD8+ T cells, B cells, and activated dendritic cells, respectively. Compared to samples with low 12-CK scores, the 12-CK high tumors were found to contain Type 3 TLS with prominent germinal centers, along with increased infiltrating CD4+ T cells, CD8+ T cells, CD20+ B cells, and comparable levels of activated dendritic cells.