Table 3.
Study design and characteristics within included studies for ablation.
| Investigators | No. of patients | No. of tumors | Tumor size | Study interval | Design | Diagnosis | CG | EG | Ref. |
|---|---|---|---|---|---|---|---|---|---|
| Carrafiello (2010) | 6 | 7 | 1–5.8 cm | 2004–2008 | Prospective | Unresectable iCCA | / | RFA | (75) |
| Kim (2011) | 13 | 17 | 0.8–8 cm | 2000–2009 | Retrospective | Unresectable iCCA | / | RFA | (76) |
| Giorgi (2011) | 10 | 12 | 2.4–7.0 cm | 2003–2010 | Retrospective | Unresectable iCCA | / | RFA | (77) |
| Brandi (2020) | 29 | 117 | 0.5–4.8cm | 2014–2019 | retrospective | unresectable iCCA | / | RFA | (78) |
| Yu (2011) | 15 | 24 | 1.3–9.9 cm | 2006–2010 | Prospective | iCCA | / | MWA | (87) |
| Zhang (2017) | 107 | 171 | <5 cm | 2009–2016 | Retrospective | Recurrent iCCA | / | MWA | (88) |
| Xu (2019) | 121 | 136 | <5 | 2011–2017 | Retrospective | Recurrent iCCA | SR (n = 65) | MWA (n = 56) | (89) |
| Belfiore (2020) | 8 | 8 | 5.6–267.2 cm3 | 2015–2019 | Prospective | Unresectable iCCA | / | IRE | (98) |
| 7 | 7 | 23.4–159.5 cm3 | 2015–2019 | Prospective | Unresectable pCCA |
iCCA, intrahepatic cholangiocarcinoma; pCCA, perihilar cholangiocarcinoma; RFA, radiofrequency ablation; MWA, microwave ablation; SR, surgical resection; IRE, irreversible electroporation; CG, control group; EG, experimental group.