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. 2021 Jun 29;12:691536. doi: 10.3389/fimmu.2021.691536

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Copyright © 2021 Ruiz-García, Muñoz-Sánchez, Naranjo, Guasp, Sabater, Saiz, Dalmau, Graus and Martinez-Hernandez

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Discrepancies identifying LGI1 antibodies by IIFA. (A) A patient’s CSF demonstrating LGI1 immunoreactivity on rat brain immunohistochemistry. Hippocampus (left panel) and cerebellum (right panel) staining patterns. (B) Left panel shows patient’s CSF reactivity on commercial IIFA LGI1 transfected cells (negative staining); Right panels show CSF reactivity on in-house IIFAs using LGI1 plus ADAM23 transfected cells (upper panels; positive staining) and GPI-LGI1 transfected cells (lower panels, negative staining). GPI: glycosyl-phosphatidylinositol anchored LGI1 (to display the protein on the cell surface).