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. 2021 Jun 29;11:668247. doi: 10.3389/fonc.2021.668247

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Copyright © 2021 Chow, Jeon, Levee, Kaur, Cedeno, Doan and Atwood

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PI3K/AKT pathway is upregulated in advanced BCC tumors. (A) KEGG analysis of the upregulated genes in advance BCC tumors highlighting the significant indicated terms. Cell cycle, p = 3.10 x 10^-8; BCC, p = 1.03 x 10^-4; HH signaling pathway, p = 2.49 x 10^-4; PI3K-AKT signaling pathway, p = 0.00675. (B) Kinase Enrichment Analysis of differentially expressed genes showing significant kinases as indicated. In descending significance to color codes: CDK2, p = 4.80 x 10^-12; CDK1, p = 1.13 x 10^-8; MAPK14, p = 2.59 x 10^-6; GSK3B, p = 5.42 x 10^-6; CDK15, p = 3.88 x 10^-4; CDK14, p = 4.39 x 10^-4; CDK18, p = 4.94 x 10^-4; CDK11A, p = 6.23 x 10^-4; MAPK1, p = 0.00460; AKT1, p = 0.00534; MAP3K10, p = 0.00641; CSNK2A1, p = 0.00796; MAPK9, p = 0.00828; RPS6KA5, p = 0.0123; CSNK2A2, p = 0.0165; CSNK1E, p = 0.0268; CSNK1D, p = 0.0275; PRKCB, p = 0.0281; RPS6KA1, p = 0.0332. (C) Heat map of the differentially expressed PI3K pathway genes in advanced human BCCs compared to patient-matched normal skin. X mark, absence of data.