Table 1.

Oxygenation, lung mechanics, maximum pressure swings, and other injury indicators generated in our COVID-19 model for different levels of respiratory effort on 100% oxygen, data presents mean ± sd across the population of 10 patients

	VT = 7 (ml/kg) RR = 14 (bpm)	VT = 7 (ml/kg) RR = 20 (bpm)	VT = 7 (ml/kg) RR = 30 (bpm)	VT = 10 (ml/kg) RR = 14 (bpm)	VT = 10 (ml/kg) RR = 20 (bpm)	VT = 10 (ml/kg) RR = 30 (bpm)
$P_{\mathit{MIN}}$(cmH2O)	− 12.4 ± 0.3	− 17.4 ± 0.3	− 25.3 ± 0.2	− 17.8 ± 0.4	− 24.5 ± 0.4	− 35.4 ± 0.2
SaO2 (%)	83.8 ± 5.1	84.1 ± 5	93.5 ± 1.4	84.1 ± 5	89.7 ± 2.3	97.6 ± 0.8
PaO2 (mmHg)	52.6 ± 7.1	49.2 ± 6.2	66.7 ± 4.7	48.9 ± 6.3	55.8 ± 4.4	98.4 ± 13.2
PF ratio (mmHg)	52.6 ± 7.1	49.2 ± 6.2	66.7 ± 4.7	48.9 ± 6.3	55.8 ± 4.4	98.4 ± 13.2
Phys. Shunt (%)	48.9 ± 4.7	48.8 ± 4.7	38.5 ± 1.7	48.8 ± 4.7	43.5 ± 2.6	31.7 ± 1.7
Phys. VD (ml)	187.4 ± 5.6	185.6 ± 6.6	187 ± 4.5	258.5 ± 10.5	255 ± 8.6	255.1 ± 6.6
VD/VT	0.38 ± 0.01	0.38 ± 0.01	0.38 ± 0.01	0.37 ± 0.02	0.37 ± 0.01	0.37 ± 0.01
PaCO2 (mmHg)	51.8 ± 1.5	37.3 ± 1.6	25 ± 0.6	36.4 ± 1.5	25.9 ± 0.8	17.2 ± 0.4
EELV (ml)	1678.9 ± 35.3	1773.5 ± 36.3	1933.6 ± 37.3	1718.8 ± 35.7	1844.9 ± 34.5	2064.6 ± 31
VT (ml)	487.7 ± 2.1	487.9 ± 2.2	489.6 ± 0.7	695.9 ± 1.9	695 ± 2.8	697.5 ± 1.3
Compliance (ml/cmH2O)	63 ± 1.4	39.6 ± 0.9	25 ± 0.3	64.7 ± 1.4	41.3 ± 0.7	26 ± 0.3
DP (cmH2O)	7.7 ± 0.2	12.3 ± 0.2	19.6 ± 0.2	10.8 ± 0.2	16.8 ± 0.3	26.9 ± 0.3
Power (J/min)	1.6 ± 0.1	4.7 ± 0.1	12.9 ± 0.2	3.0 ± 0.1	8.9 ± 0.2	24.9 ± 0.3
Total Strain	0.29 ± 0.006	0.35 ± 0.005	0.44 ± 0.008	0.44 ± 0.008	0.51 ± 0.011	0.65 ± 0.016
$\mathrm{\Delta }$ PPL (cmH2O)	12.0 ± 0.3	21.6 ± 0.5	33.8 ± 0.4	16.8 ± 0.4	29.2 ± 0.5	46.2 ± 0.5
$\mathrm{\Delta }$ PTP (cmH2O)	4.7 ± 0.1	9.8 ± 0.2	17.9 ± 0.3	6.3 ± 0.2	13.1 ± 0.3	24.2 ± 0.3