FIGURE 1.

(a) Estimated GFR from cystatin C and creatinine ratio in patients with a biopsy diagnosis of either diabetic kidney disease (DKD; n = 17) or minimal change disease (MCD; n = 12). (b) Estimated GFR from cystatin C and creatinine in a theoretical model of the human glomerular filtration barrier. In silico simulations were performed either assuming a thickness of the glomerular basement membrane (GBM; 300 nm) from a glomerulus from a patient with MCD or a hypertrophic GBM being three times thicker (900 nm) from patient with DKD. It was assumed that GFR remained constant as a result of tubuloglomerular feedback, thus implying a three times higher effective filtration pressure across the glomerulus in the hypertrophic condition. *** p < 0.001.