FIGURE 3.

Glomerular sieving coefficients versus the Stokes‐Einstein radii of the solute proteins for three different thicknesses of the glomerular basement membrane 300 nm (and an effective filtration pressure [EFP] of 10 mmHg), 600 nm (EFP 20 mmHg), 900 nm (EFP 30 mmHg). Also shown are experimentally measured sieving coefficients for β₂‐microglobulin (Norden et al., 2001) (black square) and myoglobin (Lund et al., 2003) (black triangle). The sieving coefficient of a 3.05 nm protein (neutral horseradish peroxidase nHRP [Lund et al., 2003]; solid star) will be practically unaltered by the thickening of the renal filter