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. 2021 Jul 12;9(7):e002444. doi: 10.1136/jitc-2021-002444

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Affinity attenuation of the HER-2 and CD3 arms of HER-2/CD3 IgG BsAb. (A) Biosensor kinetics demonstrating an approximately sevenfold and ninefold affinity reduction of the pertuzumab arm binding to soluble human HER-2 antigen. The exact attenuating mutations are listed in the top left corner. (B) The impact of CD3 attenuating mutations within the IgG BsAb was measured using competition FACS displacement of a wild-type SP34 monoclonal antibody labeled with phycoerythrin. BsAb, bispecific antibody.