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. 2021 Jul 12;9(7):e002444. doi: 10.1136/jitc-2021-002444

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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(A) Impact of attenuating HER-2/CD3 BsAb affinity to CD3 (upper left panels), (B) HER-2 (upper right panels), or (C) both CD3 and HER-2 (bottom panels) on in vitro T cell redirected lysis activity towards OVCAR3 and SKOV3 tumor cells. On the upper panels, chSP34/Pertuz IgG BsAb and chSP34/Pertuz IgG BsAb2 are duplicates. BsAb, bispecific antibody; mAb, monoclonal antibody.