FIGURE 8.

Analysis of mutations in the P.1 variant. (A) Mutation map of the spike protein of P.1. (B) Structural representation of spike with ACE2. P.1 S protein mutations are presented in black. NTD (green), RBD (blue), SD1 (purple), SD2 (light blue), and S2 (magenta) are illustrated. The other S protein monomers are illustrated in gray and white. (C) Frequency of P.1 variant S protein mutations from December 2019 to April 30, 2021. Interaction of (D) 417T with C102 Nab (green), (E) 484K with C121 Nab (light pink), and (F) 501Y with hACE2 (yellow). The mutations are colored in black and interaction with adjacent residues are demonstrated by dashed lines. (G) Genome of the SARS-CoV-2 P.1 variant with identified nucleotides substitution, deletions, and insertions. Figures were generated using Biorender, PyMOL, and RStudio. *Overlapping curves.