TABLE 2.

Synonymous, non-synonymous, and deletion mutations in the B.1.1.7 (United Kingdom) variant.

Variant	Protein (gene)	Genome nucleotide mutation	S or NS	AA mutation Rambaut et al., 2020	Domain	Frequency* (%)	Effect
B.1.1.7	NSP2 (ORF1ab)	C913T	S			N/A	N/A
	NSP3 (ORF1ab)	C3267T	NS	T183I		76.14	N/A
		C5388A	NS	A890D		76.24	N/A
		C5986T	S			N/A	N/A
		T6954C	NS	I1412T		75.21	N/A
	NSP6 (ORF1ab)	11288-11296del	NS	ΔS106/ ΔG107/ΔF108		87.61	N/A
	NSP12 (ORF1ab)	C14676T	S			N/A	N/A
		C15279T	S			N/A	N/A
	NSP13 (ORF1ab)	C16176T	S			N/A	N/A
	S	21765-21770del	NS	ΔH69/ΔV70	NTD	75.13	Antibody escape Covid-19 Genomic UK Consortium, 2021
		21991-21993del	NS	ΔY144	NTD	76.91	Decreases infectivity, Antibody escape Li Q. et al., 2020
		A23063T	NS	N501Y	RBD	80.16	Increases affinity for hACE2 Wu et al., 2017
		C23271A	NS	A570D	SD1	76.30
		A23403G	NS	D614G	SD2	99.29	Moderate increase in transmissibility Li Q. et al., 2020; Wu et al., 2017
		C23709A	NS	P681H	SD2	79.18	N/A
		C23709T	NS	T716I		75.37	N/A
		T24506G	NS	S982A	HR1	74.61	N/A
		G24914C	NS	D1118H		74.82	N/A
	NS8 (ORF8)	C27972T	NS	Q27stop		76.05	Inactivation of NS8 Pereira, 2020
		G28048T	NS	R52I		76.00	N/A
		A28111G	NS	Y73C		76.07	N/A
	M	T26801C	S			N/A	N/A
	N	G28280C	NS	D3L		75.53	N/A
		A28281T	NS	D3L		75.53	N/A
		T28282A	NS	D3L		75.53	N/A
		C28977T	NS	S235F		76.34	N/A

*Mutation frequency as of April 30, 2021.