Fig. 7.

Characteristics of TIM of primary tissue. (A) Classification of the TIM in 87 colorectal cancer samples. (B) No association between TIM status and Ca-IIP group (Fisher exact test). The TIM status was associated with intrinsic HLA-I expression (C) but not intrinsic HLA-II expression (D) in CCOs (Wilcoxon-rank sum test). (E) Patient survival based on TIM status (log-rank test). (F) High CD8⁺ T cell exhaustion score in MSI-H/hypermutated tumors (Wilcoxon-rank sum test). TIM, tumor immune microenvironment; CCO, colorectal cancer organoid; Ca-IIP, Cancer cells with intrinsic immunogenic properties; MSI-H, microsatellite instability high