Table 1.
Main characteristics of HBsAg-positive mothers and their babies from two different dose of HB vaccine
| Variables | 10 μg (n = 478) | 20 μg (n = 477) | P value |
|---|---|---|---|
| Maternal data | |||
| Age (years) | 27.3 ± 4.5 | 26.8 ± 4.6 | 0.076 |
| HBeAg positive | 154 (32.2%) | 270 (55.0%) | < 0.001 |
| HBV DNA (log10 IU/mL) | 2.6 ± 2.9 | 3.5 ± 3.2 | < 0.001 |
| HBV DNA ≥ 5 (log10 IU/mL) | 128 | 226 | < 0.001 |
| ALT (IU/L) | 15.2 ± 8.6 | 15.6 ± 13.4 | 0.593 |
| TBIL (μmol/L) | 9.9 ± 6.5 | 9.3 ± 4.0 | 0.161 |
| Infant data at birth | |||
| Sex (male) | 264 | 270 | 0.669 |
| Gestation days | 277.0 ± 6.9 | 278.4 ± 7.3 | 0.450 |
| Birth mode (vaginal delivery) | 184 (38.4%) | 210 (44.0%) | 0.083 |
| Birth weight (g) | 3625 ± 349.0 | 3508 ± 380.1 | 0.150 |
| 1-min APGAR | 9.6 ± 0.1 | 9.5 ± 0.2 | 0.140 |
Abbreviations: ALT alanine aminotransferase, HBeAg hepatitis B e antigen, HBsAg hepatitis B surface antigen, HBV hepatitis B virus, TBIL total bilirubin