Table 3.
The response differences to HB vaccine in infants born to HBsAg-positive mothers in two groups
| Infant response | Maternal HBV DNA < 5 log10 IU/mL | Maternal HBV DNA ≥ 5 log10 IU/mL | ||||
|---|---|---|---|---|---|---|
| 10 μg (n = 350) |
20 μg (n = 251) |
P value | 10 μg (n = 128) |
20 μg (n = 226) |
P value | |
| Failure | 0 (0%) | 1 (0.4%) | 0.418 | 5 (3.9%) | 7 (3.1%) | 0.922 |
| Non-responder | 11 (3.1%) | 5 (2.0%) | 0.387 | 6 (4.7%) | 2 (0.9%) | 0.052 |
| Low-responder | 67 (19.1%) | 25 (10.0%) | 0.002 | 17 (13.3%) | 24 (10.6%) | 0.452 |
| Middle-responder | 192 (54.9%) | 114 (45.4%) | 0.022 | 62 (48.4%) | 124 (54.9%) | 0.244 |
| High-responder | 80 (22.9%) | 106 (42.2%) | < 0.001 | 38 (29.7%) | 69 (30.5%) | 0.868 |
Abbreviations: HB hepatitis B, HBsAg hepatitis B surface antigen