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. 2021 Jul 13;9:57. doi: 10.1186/s40364-021-00289-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Identification of prognostic and predictive miRNAs in the IRE cohort. Forest plots indicating miRNAs with statistically significant (p < 0.05) impact on EFS and OS in the IRE cohort (a). Volcano plot showing the differentially expressed miRNAs between 39 platinum sensitive and 19 platinum resistant tumor samples (b). Box plots displaying miRNAs with statistically significant (Wilcoxon test, p < 0.05) differential expression between 39 platinum sensitive and 19 platinum resistant tumors (c). Heatmap illustrating the unsupervised hierarchical clustering analysis of the 15 miRNAs predictive of platinum sensitivity state (d), profiled on 39 platinum sensitive and 19 platinum resistant tumors. Abbreviations: HR = hazard ratio; sens = platinum sensitive; resist = platinum resistant