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. 2021 Jul 13;9:57. doi: 10.1186/s40364-021-00289-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Characterization of miRNA prognostic signatures in the IRE and TCGA cohorts. Kaplan-Meier survival curves of event free survival (EFS) (a), and overall survival (OS) (b), of patients with low versus high expression of the 2-miRNA prognostic signature identified in the IRE cohort (statistically significant differences when logrank test p < 0.05). Forest plot illustrating univariate Cox regression analysis for EFS (c) and OS in the TCGA of the 5 miRNAs selected for the inherent prognostic signature (d). Kaplan-Meier survival curves of event free survival (EFS) (e), and overall survival (OS) (f), of patients with low versus high expression of the TCGA 5 miRNA prognostic signature (statistically significant differences when logrank test p < 0.05). Univariate Cox regression for prognostic signatures is displayed beneath the relative Kaplan-Meier curves, inside a rectangle. Abbreviations: HR = hazard ratio